ALTERNATIVE EQUATIONS FOR DYNAMIC BEHAVIOR OF IONIC CHANNEL ACTIVATION AND INACTIVATION GATES
| Autor: | Mahmut ÖZER |
|---|---|
| Jazyk: | English<br />Turkish |
| Rok vydání: | 2003 |
| Předmět: | |
| Zdroj: | Pamukkale University Journal of Engineering Sciences, Vol 9, Iss 3, Pp 349-356 (2003) |
| Druh dokumentu: | article |
| ISSN: | 1300-7009 2147-5881 |
| Popis: | In this paper, alternative equations for dynamics of ionic channel activation and inactivation gates are proposed based on the path probability method. Dynamic behavior of a voltage-gated ionic channel is modeled by the conventional Hodgkin-Huxley (H-H) mathematical formalism. In that model, conductance of the channel is defined in terms of activation and inactivation gates. Dynamics of the activation and inactivation gates is modeled by first-order differential equations dependent on the gate variable and the membrane potential. In the new approach proposed in this study, dynamic behavior of activation and inactivation gates is modeled by a firstorder differential equation dependent on internal energy and membrane potential by using the path probability method which is widely used in statistical physics. The new model doesn't require the time constant and steadystate values which are used explicitly in the H-H model. The numerical results show validity of the proposed method. |
| Databáze: | Directory of Open Access Journals |
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