Dose sparing of induction dose of propofol by fentanyl and butorphanol: A comparison based on entropy analysis

Autor: Jasleen Kaur, Moningi Srilata, Durga Padmaja, Ramchandran Gopinath, Sukhminder Jit Singh Bajwa, Dorairay John Kenneth, Parasa Sujay Kumar, Chalumuru Nitish, Wudaru Sreedhar Reddy
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: Saudi Journal of Anaesthesia, Vol 7, Iss 2, Pp 128-133 (2013)
Druh dokumentu: article
ISSN: 1658-354X
DOI: 10.4103/1658-354X.114052
Popis: Background: The induction dose of propofol is reduced with concomitant use of opioids as a result of a possible synergistic action. Aim and Objectives: The present study compared the effect of fentanyl and two doses of butorphanol pre-treatment on the induction dose of propofol, with specific emphasis on entropy. Methods: Three groups of 40 patients each, of the American Society of Anaesthesiologistsphysical status I and II, were randomized to receive fentanyl 2 μg/kg (Group F), butorphanol 20 μg/kg (Group B 20) or 40 μg/kg (Group B 40) as pre-treatment. Five minutes later, the degree of sedation was assessed by the observer′s assessment of alertness scale (OAA/S). Induction of anesthesia was done with propofol (30 mg/10 s) till the loss of response to verbal commands. Thereafter, rocuronium 1 mg/kg was administered and endotracheal intubation was performed 2 min later. OAA/S, propofol induction dose, heart rate, blood pressure, oxygen saturation and entropy (response and state) were compared in the three groups. Statistical Analysis: Data was analyzed using ANOVA test with posthoc significance, Kruskal-Wallis test, Chi-square test and Fischer exact test. A P
Databáze: Directory of Open Access Journals