Influence of lactide vs glycolide composition of poly (lactic-co-glycolic acid) polymers on encapsulation of hydrophobic molecules: molecular dynamics and formulation studies

Autor: Anurag Dobhal, Ashu Srivastav, Prajakta Dandekar, Ratnesh Jain
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Journal of Materials Science: Materials in Medicine, Vol 32, Iss 10, Pp 1-18 (2021)
Druh dokumentu: article
ISSN: 0957-4530
1573-4838
DOI: 10.1007/s10856-021-06580-0
Popis: Highlights Microreactor-based continuous process for the synthesis of PLGA nanoparticles. Miscibility of different PLGA polymers and coumarin-6 was evaluated computationally. Flory–Huggins interaction parameter (χ) was superior for shorter PLGA chains, irrespective of their lactide to glycolide ratio. Polymer chains containing lactide to glycolide ratio of 1:1 resulted in strongest interaction with coumarin-6 due to homogeneous spatial arrangements and superior binding energy. Intra-chain interactions, spatial arrangement, inter-chain binding energies, and polymer–coumarin-6 miscibility influence coiling and flexibility of polymer chains.
Databáze: Directory of Open Access Journals
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