A conserved glutathione binding site in poliovirus is a target for antivirals and vaccine stabilisation

Autor: Mohammad W. Bahar, Veronica Nasta, Helen Fox, Lee Sherry, Keith Grehan, Claudine Porta, Andrew J. Macadam, Nicola J. Stonehouse, David J. Rowlands, Elizabeth E. Fry, David I. Stuart
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Druh dokumentu: article
ISSN: 2399-3642
DOI: 10.1038/s42003-022-04252-5
Popis: Cryo-EM structures reveal the role of glutathione (GSH) in poliovirus (PV) serotype 3 virus-like particle (VLP) stability, suggesting GSH or an analogous tight-binding antiviral offers potential for stabilizing VLP vaccines against PV.
Databáze: Directory of Open Access Journals