Combination Immunotherapy Approaches for Pancreatic Cancer Treatment

Autor: Xianliang Cheng, Gang Zhao, Yunqi Zhao
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Canadian Journal of Gastroenterology and Hepatology, Vol 2018 (2018)
Druh dokumentu: article
ISSN: 2291-2789
2291-2797
DOI: 10.1155/2018/6240467
Popis: Pancreatic ductal adenocarcinoma is a lethal malignant disease with a very low medium survival. Currently, metastatic pancreatic cancer poorly responds to conventional treatments and exhibits an acute resistance to most chemotherapy. Few approaches have been shown to be effective for metastatic pancreatic cancer treatment. Novel therapeutic approaches to treat patients with pancreatic adenocarcinoma are in great demand. Last decades, immunotherapies have been evaluated in clinical trials and received great success in many types of cancers. However, it has very limited success in treating pancreatic cancer. As pancreatic cancer poorly responds to many single immunotherapeutic agents, combination immunotherapy was introduced to improve efficacy. The combination therapies hold great promise for enhancing immune responses to achieve better therapeutic effects. This review summarizes the existing and potential combination immunotherapies for the treatment of pancreatic cancer.
Databáze: Directory of Open Access Journals
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