| Autor: |
Peng-tao Dong, Zheng Wang, Xiao-yu Li, Qing Zhang |
| Jazyk: |
čínština |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Linchuang shenzangbing zazhi, Vol 24, Iss 5, Pp 370-377 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1671-2390 |
| DOI: |
10.3969/j.issn.1671-2390.2024.05.004 |
| Popis: |
ObjectiveTo explore the potential causal relationship between obesity and IgA nephropathy through Mendelian randomization. MethodsSummary-level data from genome-wide association studies of obesity-related shapes (body mass index, percentage body fat, waist circumference & waist-to-hip ratio) and IgA nephropathy were acquired. Inverse variance weighted analysis was utilized as a primary analytical method with weighted median and MR-Egger regression supplementing the results. Sensitivity analyses were performed for testing the reliability of the results of Mendelian randomization. ResultsThe results of two-sample Mendelian randomization indicated that, according to forward inverse variance weighted analysis, BMI （OR=1.193, 95%CI：1.104～1.289, P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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