| Autor: |
Doaa S.E. Zaky, Mona Naiem, Hoda A. Eid, Zeinab R. Adawy, Sabah E. Abd-Elraheem, Zakia A.Z. Mohamed |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Egyptian Journal of Chest Disease and Tuberculosis, Vol 63, Iss 3, Pp 553-559 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
0422-7638 |
| DOI: |
10.1016/j.ejcdt.2014.03.011 |
| Popis: |
Pulmonary surfactant protein D (SP-D) is considered a candidate biomarker for lung integrity and for disease progression. In the present study, we aimed to estimate the serum levels of SP-D in patients with chronic obstructive pulmonary disease (COPD) and to assess the correlation of these biomarkers with indices of COPD severity. Subjects and methods: The study was carried out on 30 COPD male patients and 15 apparently healthy age-matched males as control. COPD patients were divided by GOLD stages into 10 patients stage I–II (group 1), and 20 patients stage III–IV (group 2). A detailed history and clinical examination, pulmonary function testing by spirometry, right ventricular function assessment by conventional echocardiography and tissue Doppler imaging were done. Serum levels of total protein and albumin were determined as well as serum SP-D by enzyme-linked immunosorbent assay in both patient and control groups was determined. Results: The serum level of SP-D was significantly higher in COPD patients than controls (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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