| Autor: |
Fernanda Silveira Cavalcante, Veronica Aiceles, Diana de Freitas Serapiao Moraes, Jorge Luiz Alves-Pereira, Tatiane Silva Faria, Cristiane da Fonte Ramos |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Acta Cirúrgica Brasileira, Vol 29, Iss 1, Pp 16-23 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
0102-8650 |
| DOI: |
10.1590/S0102-86502014000100003 |
| Popis: |
PURPOSE: To investigate the effects of the maternal caffeine consumption during pregnancy to adult male testis mice offspring. METHODS: Twenty pregnant mice were divided into control group (c) and caffeine group (cf). dams received daily saline or 20 mg/kg of caffeine subcutaneously. Male offspring were monitored daily until 13th week. The testis were used to evaluate both the proliferation (pcna) and apoptosis (bax); leptin receptor (ob-r); aromatase; follicle stimulating hormone (fshr), luteinizing hormone (lhr) and androgen receptors (ar); steroidogenic acute regulatory protein (star); vascular endothelial growth factor (vegf) and estrogen receptors (erα and erβ) by western blotting. Serum concentrations of testosterone, estradiol and leptin were measured. RESULTS: There was a significant reduction in food intake and the body mass gain (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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