Modulation of polypeptide conformation through donor–acceptor transformation of side-chain hydrogen bonding ligands

Autor: Ziyuan Song, Rachael A. Mansbach, Hua He, Kuo-Chih Shih, Ryan Baumgartner, Nan Zheng, Xiaochu Ba, Yinzhao Huang, Deepak Mani, Yun Liu, Yao Lin, Mu-Ping Nieh, Andrew L. Ferguson, Lichen Yin, Jianjun Cheng
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-017-00079-5
Popis: Hydrogen bonding plays a major role in determining the tridimensional structure of biopolymers. Here, the authors show that control over a polypeptide conformation can be achieved by altering the donor-acceptor properties of side-chain triazole units via protonation-deprotonation.
Databáze: Directory of Open Access Journals