Rifabutin and Furazolidone Could Be the Candidates of the Rescue Regimen for Antibiotic-Resistant H. pylori in Korea

Autor: Youn I Choi, Sang-Ho Jeong, Jun-Won Chung, Dong Kyun Park, Kyoung Oh Kim, Kwang An Kwon, Yoon Jae Kim, Seol So, Jeong Hoon Lee, Jin-Young Jeong, Sun-Mi Lee
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Canadian Journal of Infectious Diseases and Medical Microbiology, Vol 2019 (2019)
Druh dokumentu: article
ISSN: 1712-9532
1918-1493
DOI: 10.1155/2019/9351801
Popis: Background/Aim. In Korea, the rate of Helicobacter pylori (H. pylori) eradication has declined steadily as a result of increasing resistance to antibiotics, especially dual resistance to clarithromycin and metronidazole. However, microbiological culture data on drug-resistant H. pylori is lacking. This study evaluated the antimicrobial efficacy of candidate antibiotics against resistant H. pylori strains. Methods. After retrospectively reviewing the data from the Helicobacter Registry in Gil Medical Center (GMC) and Asan Medical Center (AMC), along with 4 reference strains, we selected the 31 single- or multidrug-resistant strains. The susceptibility of the H. pylori strains to seven antibiotics (clarithromycin, metronidazole, levofloxacin, amoxicillin, tetracycline, rifabutin, and furazolidone) and minimum inhibitory concentration were tested using the broth microdilution technique. Results. Among 31 antibiotic resistance strains for H. pylori, there were no strains resistant to rifabutin or furazolidone, which had MICs of
Databáze: Directory of Open Access Journals
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