| Autor: |
Stefanović Nikola Z., Cvetković Tatjana P., Dinić Katarina S., Mitić Branka P., Paunović Goran J., Damnjanović Ivana D., Catić-Đorđević Aleksandra K., Veličković-Radovanović Radmila M. |
| Jazyk: |
English<br />Serbian |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Hospital Pharmacology, Vol 6, Iss 2, Pp 774-784 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2334-9492 |
| Popis: |
Introduction: Two most common pharmaceutical formulation of tacrolimus (Tac) used after kidney transplantation (Tx) are immediate-release one, administered twice-daily (TacTD), and prolonged-release one, administered once-daily (Tac-OD). Aim: The aim of this study was to compare daily doses, trough concentrations (C0 ) and dose-adjusted trough concentrations (C0 /D) of Tac between patients who administered different drug formulations, Tac-TD or Tac-OD, during the first year after Tx. Additionally, the aim of the study was to compare the distribution of C0 within and beyond the target therapeutic range (8-12 ng/mL for the first 90 days and 6-10 ng/mL afterwards) after the administration of different drug formulations. Subjects and Methods: A retrospective pharmacokinetic study included 84 patients (56 on Tac-TD and 28 on Tac-OD), with a follow-up period between the first and twelfth month post-transplantation. Following pharmacokinetic data were used: daily dose, daily dose according to patient's body weight, concentration C0 and C0 /D of Tac. Results: The results of the study showed that patients on Tac-OD formulation had higher daily doses and higher C0 during 4-6 months (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
