Enhancing the Cardiovascular Health Construct With a Psychological Health Metric for Predicting Mortality Risk

Autor: Vanessa T. Dinh, MPH, Rahul Hosalli, MPH, Pricila H. Mullachery, PhD, MPH, Brooke Aggarwal, EdD, Charles A. German, MD, Nour Makarem, PhD, MS
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: JACC: Advances, Vol 3, Iss 8, Pp 101112- (2024)
Druh dokumentu: article
ISSN: 2772-963X
DOI: 10.1016/j.jacadv.2024.101112
Popis: Background: The American Heart Association’s Life’s Essential 8 (LE8) Presidential Advisory deemed psychological health foundational for cardiovascular health (CVH) but did not include it as a CVH metric. Objectives: The purpose of this study was to evaluate associations of a CVH construct enhanced with a ninth metric for psychological health based on readily administered depression screening with mortality risk in U.S. adults. Methods: Participants were 21,183 adults (mean age: 48y, 51% female, 11% Black, 15% Hispanic, 65% White) from the 2011 to 2018 National Health and Nutrition Examination Survey. The LE8 algorithm was used to assess CVH. Two enhanced CVH constructs that include a ninth psychological health metric based on depression screening using the Patient Health Questionnaires (PHQ-2 and PHQ-9) were computed. Multivariable Cox proportional hazards models compared all-cause and cause-specific mortality risk across CVH score tertiles and a priori defined categories (high: 80-100, moderate: 50-79, low: 0-49) in the overall sample and by sex and race and ethnicity. Results: There were 1,397 deaths (414 cardiovascular and 329 cancer deaths). High vs low CVH scores, enhanced with PHQ-2 and PHQ-9, were associated with 69% and 70% lower mortality risk, while a high vs low LE8 score was associated with 65% lower risk (p-trend
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