SARS-CoV-2 dual infection with Delta and Omicron variants in an immunocompetent host: a case report

Autor: Aare Abroi, Ulvi Gerst Talas, Merit Pauskar, Arina Shablinskaja, Tuuli Reisberg, Heiki Niglas, Taavi Päll, Mari Nelis, Ingrid Tagen, Pilleriin Soodla, Irja Lutsar, Kristi Huik
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: International Journal of Infectious Diseases, Vol 124, Iss , Pp 41-44 (2022)
Druh dokumentu: article
ISSN: 1201-9712
DOI: 10.1016/j.ijid.2022.08.027
Popis: Despite the high number of SARS-CoV-2 infections, only a few cases of dual infection have been reported. Here, we describe a case of COVID-19 caused simultaneously by Delta and Omicron variants in an immunocompetent individual during the early emergence of Omicron variant. A 73-year-old man was hospitalized with suspected acute coronary syndrome and a positive test result for SARS-CoV-2 RNA was received during routine testing at the hospital. He experienced mild symptoms of COVID-19 and was discharged on the ninth day. We sequenced the SARS-CoV-2 whole genome from the sample obtained on admission. The viral sequence was classified as PANGO lineage B.1.1.10 by the Galaxy pipeline; however, on detailed manual analysis, we identified the presence of both Delta and Omicron variants. After excluding the possibilities of a recombinant virus or contamination in the sample, we confirmed the presence of dual infection in this patient. We highlight that dual infections with SARS-CoV-2 may be more common than expected but are difficult to detect during the waves of one dominant variant.
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