Increased Levels of IL-23 in Peripheral Blood Mononuclear Cells of Patients With Chronic Heart Failure
| Autor: | Vajiheh Eskandari, Ali Akbar Amirzargar, Bobak Moazzami, Mohammad Jafar Mahmoudi, Zahra Rahnemoon, Samaneh Sadati, Zahra Rahmati, Fatemeh Gorzin, Mona Hedayat, Nima Rezaei |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Acta Medica Iranica, Vol 56, Iss 5 (2018) |
| Druh dokumentu: | article |
| ISSN: | 0044-6025 1735-9694 |
| Popis: | Chronic heart failure (CHF) is a complex clinical syndrome that represents the end stage of various cardiac diseases and is characterized by the inability of the heart to meet metabolic demands of the body. Many physiological systems are involved in this disease. In particular, the activation of the immune system has received considerable interest in the last decade. Evidence from both experimental and clinical trials indicates that inflammatory mediators are of importance in the pathogenesis and progression of chronic heart failure. Excessive pro-inflammatory cytokines induce contractile dysfunction, hypertrophy, and fibrosis and cell death in Cardiac myocyte. We examined the expression of IL-23 in PBMCs between CHF patients and healthy controls. In this report, we used real-time PCR assay to compare the relative expression of IL-23 in peripheral blood mononuclear cells (PBMC) from CHF patients with various heart diseases (n=42, EF |
| Databáze: | Directory of Open Access Journals |
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