| Autor: |
Roland Grundtner, Klaus Dornmair, Ralf Dahm, Alexander Flügel, Naoto Kawakami, Manuel Zeitelhofer, Lucia Schoderboeck, Mikhail Nosov, Edgar Selzer, Martin Willheim, Michael Kiebler, Hartmut Wekerle, Hans Lassmann, Monika Bradl |
| Jazyk: |
angličtina |
| Rok vydání: |
2007 |
| Předmět: |
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| Zdroj: |
Neurobiology of Disease, Vol 28, Iss 3, Pp 261-275 (2007) |
| Druh dokumentu: |
article |
| ISSN: |
1095-953X |
| DOI: |
10.1016/j.nbd.2007.05.006 |
| Popis: |
Myelin degeneration in the central nervous system (CNS) is often associated with elevated numbers of T cells in brain and spinal cord (SC). In some degenerative diseases, this T cell immigration has no clinical relevance, in others, it may precede severe inflammation and tissue damage. We studied T cells in the myelin-degenerative SC of transgenic (tg) Lewis rats overexpressing the proteolipid protein (PLP). These lymphocytes are TH1/TC1 cells and represent different T cell clones unique to individual animals. The SC-infiltrating CD8+ T cell pool is more restricted than its CD4+ counterpart, possibly due to constrictions in the peripheral CD8+ T cell repertoire. Some SC-infiltrating T cells are highly motile and cover large distances within their target tissue, others are tethered to MHC class II+ microglia cells. The activation of the tethered cells may trigger the formation of inflammatory foci and could pave the way for inflammation in degenerative CNS disease. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect