Weekend effect in upper gastrointestinal bleeding: a systematic review and meta-analysis

Autor: Pei-Ching Shih, Shu-Jung Liu, Sung-Tse Li, Ai-Chen Chiu, Po-Chuan Wang, Lawrence Yu-Min Liu
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: PeerJ, Vol 6, p e4248 (2018)
Druh dokumentu: article
ISSN: 2167-8359
DOI: 10.7717/peerj.4248
Popis: Aim To perform a systematic review and meta-analysis of the weekend effect on the mortality of patients with upper gastrointestinal bleeding(UGIB). Methods The review protocol has been registered in the PROSPERO International Prospective Register of Systematic Reviews (registration number: CRD42017073313) and was written according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. We conducted a search of the PUBMED, COCHRANE, EMBASE and CINAHL databases from inception to August 2017. All observational studies comparing mortality between UGIB patients with weekend versus weekday admissions were included. Articles that were published only in abstract form or not published in a peer-reviewed journal were excluded. The quality of articles was assessed using the Newcastle-Ottawa Scale. We pooled results from the articles using random-effect models. Heterogeneity was evaluated by the chi-square-based Q-test and I2test. To address heterogeneity, we performed sensitivity and subgroup analyses. Potential publication bias was assessed via funnel plot. Results Eighteen observational cohort studies involving 1,232,083 study patients were included. Weekend admission was associated with significantly higher 30-day or in-hospital mortality in all studies (OR = 1.12, 95% CI [1.07–1.17], P
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