m6A-binding proteins: the emerging crucial performers in epigenetics

Autor:	Yanchun Zhao, Yuanfei Shi, Huafei Shen, Wanzhuo Xie
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	N6-methyladenosine m6A-binding proteins Cancer Virus Immunity Adipogenesis Diseases of the blood and blood-forming organs RC633-647.5 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Journal of Hematology & Oncology, Vol 13, Iss 1, Pp 1-14 (2020)
Druh dokumentu:	article
ISSN:	1756-8722
DOI:	10.1186/s13045-020-00872-8
Popis:	Abstract N6-methyladenosine (m6A) is a well-known post-transcriptional modification that is the most common type of methylation in eukaryotic mRNAs. The regulation of m6A is dynamic and reversible, which is erected by m6A methyltransferases (“writers”) and removed by m6A demethylases (“erasers”). Notably, the effects on targeted mRNAs resulted by m6A predominantly depend on the functions of different m6A-binding proteins (“readers”) including YT521-B homology (YTH) domain family, heterogeneous nuclear ribonucleoproteins (HNRNPs), and insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs). Indeed, m6A readers not only participate in multiple procedures of RNA metabolism, but also are involved in a variety of biological processes. In this review, we summarized the specific functions and underlying mechanisms of m6A-binding proteins in tumorigenesis, hematopoiesis, virus replication, immune response, and adipogenesis.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/d0cf1bc86a914ad99074879efdc84822 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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