Extraneous E-Cadherin Engages the Deterministic Process of Somatic Reprogramming through Modulating STAT3 and Erk1/2 Activity
| Autor: | Yu-Hao Liu, Chien-Chang Chen, Yi-Jen Hsueh, Li-Man Hung, David Hui-Kang Ma, Hung-Chi Chen, Wen-Bin Len, Yaa-Jyuhn J. Meir |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Cells, Vol 10, Iss 2, p 284 (2021) |
| Druh dokumentu: | article |
| ISSN: | 10020284 2073-4409 |
| DOI: | 10.3390/cells10020284 |
| Popis: | Although several modes of reprogramming have been reported in different cell types during iPSC induction, the molecular mechanism regarding the selection of different modes of action is still mostly unknown. The present study examined the molecular events that participate in the selection of such processes at the onset of somatic reprogramming. The activity of STAT3 versus that of Erk1/2 reversibly determines the reprogramming mode entered; a lower activity ratio favors the deterministic process and vice versa. Additionally, extraneous E-cadherin facilitates the early events of somatic reprogramming, potentially by stabilizing the LIF/gp130 and EGFR/ErbB2 complexes to promote entry into the deterministic process. Our current findings demonstrated that manipulating the pSTAT3/pErk1/2 activity ratio in the surrounding milieu can drive different modes of action toward either the deterministic or the stochastic process in the context of OSKM-mediated somatic reprogramming. |
| Databáze: | Directory of Open Access Journals |
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