Proof of concept of an accelerometer as a trigger for unilateral diaphragmatic pacing: a porcine model

Autor: Tobias Kratz, Roman Ruff, Timo Koch, Anne-Sophie Kronberg, Johannes Breuer, Boulos Asfour, Ulrike Herberg, Benjamin Bierbach
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: BioMedical Engineering OnLine, Vol 22, Iss 1, Pp 1-12 (2023)
Druh dokumentu: article
ISSN: 1475-925X
DOI: 10.1186/s12938-023-01119-6
Popis: Abstract Background Unilateral diaphragmatic paralysis in patients with univentricular heart is a known complication after pediatric cardiac surgery. Because diaphragmatic excursion has a significant influence on perfusion of the pulmonary arteries and hemodynamics in these patients, unilateral loss of function leads to multiple complications. The current treatment of choice, diaphragmatic plication, does not lead to a full return of function. A unilateral diaphragmatic pacemaker has shown potential as a new treatment option. In this study, we investigated an accelerometer as a trigger for a unilateral diaphragm pacemaker (closed-loop system). Methods Seven pigs (mean weight 20.7 ± 2.25 kg) each were implanted with a customized accelerometer on the right diaphragmatic dome. Accelerometer recordings (mV) of the diaphragmatic excursion of the right diaphragm were compared with findings using established methods (fluoroscopy [mm]; ultrasound, M-mode [cm]). For detection of the amplitude of diaphragmatic excursions, the diaphragm was stimulated with increasing amperage by a cuff electrode implanted around the right phrenic nerve. Results Results with the different techniques for measuring diaphragmatic excursions showed correlations between accelerometer and fluoroscopy values (correlation coefficient 0.800, P
Databáze: Directory of Open Access Journals
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje