Prognostic factors of progressive fibrotic hypersensitivity pneumonitis: a large, retrospective, multicentre, observational cohort study
| Autor: | Esteban Cano-Jiménez, Ana Villar Gómez, Eduardo Velez Segovia, Myriam Aburto Barrenechea, Jacobo Sellarés Torres, Joel Francesqui, Karina Portillo Carroz, Alan Jhunior Solis Solis, Orlando Acosta Fernández, Ana Belén Llanos González, Jaume Bordas-Martinez, Eva Cabrera Cesar, Eva Balcells Vilarnau, Diego Castillo Villegas, Ana Reyes Pardessus, Coral González Fernández, Marta García Moyano, Amaia Urrutia Gajate, Andrés Blanco Hortas, María Molina-Molina |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | ERJ Open Research, Vol 10, Iss 1 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2312-0541 23120541 |
| DOI: | 10.1183/23120541.00405-2023 |
| Popis: | Background Fibrotic hypersensitivity pneumonitis (fHP) is an immune-mediated interstitial lung disease caused by sensitisation to chronic allergen inhalation. This study aimed to determine prognostic indicators of progression and mortality in fHP. Methods This was a retrospective, multicentre, observational, cross-sectional cohort study of consecutive patients diagnosed with fHP from 1 January 2012 to 31 December 2021. Multivariate Cox regression analyses were used to calculate hazard ratios (HRs) with 95% confidence intervals for predictors of progression and survival. Results A total of 403 patients were diagnosed with fHP: median (interquartile range) age 66.5 (14.0) years, 51.9% females and 55.1% never-smokers. The cause of fHP was mainly fungal (39.7%) or avian (41.4%). Lung biopsy was performed in 269 cases (66.7%). In the whole cohort the variables that were related to mortality or lung transplant were older age (HR 1.08; p |
| Databáze: | Directory of Open Access Journals |
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