Safety and efficacy of lidocaine plus epinephrine on intraoperative bleeding in abdominal myomectomy: A double‐blind clinical trial

Autor: Mandana Mansour‐Ghanaei, Fatemeh Hosseinzadeh, Seyedeh Hajar Sharami, Gelareh Biazar, Fatemeh Noori, Seyed Mohammad Asgari‐Ghalebin
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Health Science Reports, Vol 5, Iss 2, Pp n/a-n/a (2022)
Druh dokumentu: article
ISSN: 2398-8835
DOI: 10.1002/hsr2.551
Popis: Abstract Background Uterine fibroid is a common benign pelvic tumor and abdominal myomectomy may cause excessive intraoperative bleeding, which may lead to adverse outcomes. Objective This study was planned to evaluate the effectiveness of the injection of lidocaine plus epinephrine to reduce intraoperative bleeding in abdominal myomectomy. Methods During October 2019 and May 2020, 60 eligible women with uterine fibroids were enrolled in a randomized controlled trial. Our patients were divided into two groups of lidocaine plus epinephrine defined as Group L and placebo defined as Group P. In group L, lidocaine 3 mg/kg plus 0.5 ml of adrenaline which reached to 50 cc with saline solution and in group P, 50 ml of normal saline was used. Both the combined solution and normal saline were infiltrated to the serous and myometrium above and around the fibroid before incision. Patients' demographic data, total operative time, hemoglobin changes, and the degree of surgical difficulty were evaluated and compared between the two groups. Results There was no significant difference between the two groups in terms of demographic data. Hemoglobin changes (p
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