Peptídeos de conformação restrita induzida pela incorporação de unidades (aza)lactâmicas Conformationally constrained induced peptides containing (aza)lactam units
| Autor: | Adriana Raffin Pohlmann, Jean-Charles Quirion, Dominique Guillaume, Henri-Philippe Husson |
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| Jazyk: | English<br />Spanish; Castilian<br />Portuguese |
| Rok vydání: | 1999 |
| Předmět: | |
| Zdroj: | Química Nova, Vol 22, Iss 6, Pp 828-837 (1999) |
| Druh dokumentu: | article |
| ISSN: | 0100-4042 1678-7064 |
| DOI: | 10.1590/S0100-40421999000600010 |
| Popis: | Conformational constraint is an approach which can be used to restrict the flexibility of peptide molecules and to provide information on the topographical requirements of receptors. The incorporation of conformationally constrained units in a peptide can lead to peptide analogues that present numerous advantages such as the potentialization of the pharmacological activity and the decrease of enzymatic degradation. This review discusses the peptide analogues containing a lactam or azalactam unit in their sequences. Of particular interest has been the replacement of a dipeptide motif in a peptide that simulates a beta-turn. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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