Evaluation of Prostate Imaging Reporting and the PI-RADS Version 2 Data System for Prostate Cancer Detection: a Retrospective Single-Center Study
| Autor: | Lora Grbanović, Lucija Kovačević, Tomislav Kuliš, Željko Kaštelan, Marko Kralik, Stjepan Ivandić, Maja Prutki |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Acta Clinica Croatica, Vol 63., Iss Supplement 2, Pp 14-20 (2024) |
| Druh dokumentu: | article |
| ISSN: | 0353-9466 1333-9451 |
| DOI: | 10.20471/acc.2024.63.s2.2 |
| Popis: | This retrospective study aimed to evaluate the performance of multiparametric MRI (mpMRI) interpreted according to the Prostate Imaging Reporting and Data System (PIRADS) version 2 (v2) in detecting clinically significant prostate cancer (csPCa). The study included 62 patients with a clinical suspicion of prostate cancer who underwent mpMRI of the prostate interpreted according to the PI-RADS v2 between January 2018 and December 2018. Histopathologic findings were considered positive if csPCa was found; otherwise, clinical follow-up of at least 4 years was required to rule out the presence of csPCa. Diagnostic accuracy of PI-RADS v2 was calculated using score cutoffs of 3 and 4. Out of 114 lesions detected on mpMRI, 21 were identified as csPCa. The detection rates of PI-RADS scores 1-5 for detecting csPCa were 0%, 5.1%, 8.3%, 47.1%, and 87.5%, respectively. PI-RADS ≥4 cutoff yielded higher specificity (83.9%) and positive predictive value (93%) for detecting csPCa than PI-RADS ≥3 (specificity 41.9%; positive predictive value 26%), but exhibited lower sensitivity (71.4% versus 90.5%, respectively) and missed 28.6% of csPCa. In conclusion, better csPCa detection with PI-RADS v2 cutoff set at 3 comes at the cost of lower specificity and more unnecessary biopsies. |
| Databáze: | Directory of Open Access Journals |
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