Interocular Symmetry in Retinal Nerve Fiber Layer Thickness in Children: The Hong Kong Children Eye Study

Autor: Xiu Juan Zhang, Yu Meng Wang, Zhenzhen Jue, Hei-Nga Chan, Yi Han Lau, Wei Zhang, Ka Wai Kam, Patrick Ip, Alvin L. Young, Clement C. Tham, Chi Pui Pang, Li Jia Chen, Jason C. Yam
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Ophthalmology and Therapy, Vol 12, Iss 6, Pp 3373-3382 (2023)
Druh dokumentu: article
ISSN: 2193-8245
2193-6528
DOI: 10.1007/s40123-023-00825-7
Popis: Abstract Introduction The aim of this work is to determine the interocular differences in peripapillary retinal nerve fiber layer (p-RNFL) thickness and its associations among school children in Hong Kong. Methods We conducted a population-based study including 4034 children aged 6–8 years from the Hong Kong Children Eye Study (HKCES). All participants received comprehensive ocular examinations where p-RNFL thickness was measured using spectral-domain optical coherence tomography (SD-OCT). The degree of symmetry between both eyes was analyzed and represented by intraclass correlation coefficient (ICC) values. Multivariable linear regression analysis was used to investigate the associations between ocular and systemic factors with p-RNFL thickness difference. Results The study included 4034 children with a mean age of 7.61 ± 0.98 years. The mean global p-RNFL thickness was 106.60 ± 9.41 μm in right eyes and 105.99 ± 9.30 μm in left eyes. The ICC for global p-RNFL difference was 0.866 (95% CI 0.858–0.873, p
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