| Autor: |
Karina Banasik, Johanne M Justesen, Malene Hornbak, Nikolaj T Krarup, Anette P Gjesing, Camilla H Sandholt, Thomas S Jensen, Niels Grarup, Asa Andersson, Torben Jørgensen, Daniel R Witte, Annelli Sandbæk, Torsten Lauritzen, Bernard Thorens, Søren Brunak, Thorkild I A Sørensen, Oluf Pedersen, Torben Hansen |
| Jazyk: |
angličtina |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 6, Iss 1, p e16542 (2011) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0016542 |
| Popis: |
Candidate genes for non-alcoholic fatty liver disease (NAFLD) identified by a bioinformatics approach were examined for variant associations to quantitative traits of NAFLD-related phenotypes.By integrating public database text mining, trans-organism protein-protein interaction transferal, and information on liver protein expression a protein-protein interaction network was constructed and from this a smaller isolated interactome was identified. Five genes from this interactome were selected for genetic analysis. Twenty-one tag single-nucleotide polymorphisms (SNPs) which captured all common variation in these genes were genotyped in 10,196 Danes, and analyzed for association with NAFLD-related quantitative traits, type 2 diabetes (T2D), central obesity, and WHO-defined metabolic syndrome (MetS).273 genes were included in the protein-protein interaction analysis and EHHADH, ECHS1, HADHA, HADHB, and ACADL were selected for further examination. A total of 10 nominal statistical significant associations (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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