Treatment-associated survival outcomes in real-world patients with de novo metastatic triple-negative breast cancer: Age as a significant treatment effect-modifier

Autor: Wei-Pang Chung, Chun-Ting Yang, Hsuan-Ying Chen, Ching-Yen Su, Hsin-Wei Su, Huang-Tz Ou
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of the Formosan Medical Association, Vol 121, Iss 1, Pp 319-328 (2022)
Druh dokumentu: article
ISSN: 0929-6646
DOI: 10.1016/j.jfma.2021.04.028
Popis: Purpose: Evidence for optimizing the first-line chemotherapy for patients with metastatic triple-negative breast cancer (mTNBC) is lacking. This study assessed the utilization patterns of chemotherapy and associated survival outcomes in de novo mTNBC patients. Methods: Taiwan's cancer registry was utilized to extract study patients with newly-diagnosed breast cancer during 2011–2015 and confirmed metastatic triple-negative status.The patients’ medical records (e.g., diseases, treatments) and death status were obtained from the National Health Insurance Research Database. Utilization of first-line chemotherapy regimens was analyzed and associated survival outcomes were assessed using Cox models. Results: 93.60% of the mTNBC patients (n = 297) received chemotherapy, where combination regimens (75.54%) were more common than single-agent regimens (24.46%) in the first-line setting. A non-statistically lower all-cause death associated with combination versus single-agent chemotherapy (hazard ratio: 0.830 [0.589, 1.168]) was observed. Age was identified as a significant effect-modifier in treatment-associated survival outcomes (p = 0.008); younger patients (aged
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