Autor: |
Wei-Pang Chung, Chun-Ting Yang, Hsuan-Ying Chen, Ching-Yen Su, Hsin-Wei Su, Huang-Tz Ou |
Jazyk: |
angličtina |
Rok vydání: |
2022 |
Předmět: |
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Zdroj: |
Journal of the Formosan Medical Association, Vol 121, Iss 1, Pp 319-328 (2022) |
Druh dokumentu: |
article |
ISSN: |
0929-6646 |
DOI: |
10.1016/j.jfma.2021.04.028 |
Popis: |
Purpose: Evidence for optimizing the first-line chemotherapy for patients with metastatic triple-negative breast cancer (mTNBC) is lacking. This study assessed the utilization patterns of chemotherapy and associated survival outcomes in de novo mTNBC patients. Methods: Taiwan's cancer registry was utilized to extract study patients with newly-diagnosed breast cancer during 2011–2015 and confirmed metastatic triple-negative status.The patients’ medical records (e.g., diseases, treatments) and death status were obtained from the National Health Insurance Research Database. Utilization of first-line chemotherapy regimens was analyzed and associated survival outcomes were assessed using Cox models. Results: 93.60% of the mTNBC patients (n = 297) received chemotherapy, where combination regimens (75.54%) were more common than single-agent regimens (24.46%) in the first-line setting. A non-statistically lower all-cause death associated with combination versus single-agent chemotherapy (hazard ratio: 0.830 [0.589, 1.168]) was observed. Age was identified as a significant effect-modifier in treatment-associated survival outcomes (p = 0.008); younger patients (aged |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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