| Autor: |
Elin Uzunel, MD, Ann-Charlotte Grahn Kronhed, RPT, PhD, Christina Kaijser Alin, RPT, PhD, Aisha Siddiqah Ahmed, PhD, Per Wändell, MD, PhD, Helena Salminen, MD, PhD |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Archives of Rehabilitation Research and Clinical Translation, Vol 5, Iss 4, Pp 100297- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2590-1095 |
| DOI: |
10.1016/j.arrct.2023.100297 |
| Popis: |
Objective: Primary purpose was to examine the effects of exercise and use of a spinal orthosis on quality of life (QoL). Secondary, to explore the effects of above-mentioned interventions on plasma levels of potential markers of pain: substance P (SP), calcitonin gene-related peptide (CGRP), and interleukin-6 (IL-6). Design: Randomized controlled trial. Setting: Community-dwelling women in Stockholm. Participants: A total of 113 women aged 60-93 years suffering from back pain and self-reported osteoporosis (n=113). Interventions: The randomized controlled trial was 3-armed: participation in an equipment exercise group, treatment with an activating spinal orthosis or controls. The intervention time was 6 months. Main Outcome Measure(s): QoL (QUALEFFO-41 and SF-36), plasma levels of SP, CGRP, and IL-6 measured at baseline and after 6 months in all 3 arms. Results: No improvement of QoL was found. Comparing change in mobility (QUALEFFO-41), the effect in least squares means was lower in the spinal orthosis group compared with controls. In the exercise group, the role emotional score (SF-36) deteriorated during the intervention. Effect size varied between 0.02 and 0.6. There was no change in the levels of CGRP or SP, while IL-6 levels were lower at 6 months in the spinal orthosis group compared with the other groups. At least 1 previous vertebral fracture was verified by X-ray in 46 women. Conclusion: The interventions showed none or negative effect on QoL, which was unexpected. The modest effect size may prompt a cautious interpretation. We found a lowering of IL-6 levels in the spinal orthosis group, but more studies are needed. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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