Enhanced Inflammatory Status in Patients with Simple Central Obesity in Absence of Metabolic Syndrome
| Autor: | Muhamed T Osman, Hanis Saimin, Nadzimah Mohd Nasir, Suraya Abdul Razak, Zaliha Ismail, Hapizah Mohd Nawawi |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Journal of Clinical and Diagnostic Research, Vol 13, Iss 3, Pp EC09-EC14 (2019) |
| Druh dokumentu: | article |
| ISSN: | 2249-782X 0973-709X |
| DOI: | 10.7860/JCDR/2019/40006.12695 |
| Popis: | Introduction: Abdominal obesity is associated with cardiovascular risk factors. Metabolic Syndrome (MS) describes a constellation of metabolic abnormalities, including abdominal obesity. However, there is limited data on the comparison of inflammatory biomarkers in centrally obese subjects without MS. Aim: To examine the biomarkers of inflammation in subjects with MS, central obesity without MS, and normal controls. Materials and Methods: This was a cross-sectional study involving 501 subjects categorised into MS, central obesity without MS (COBXMS), and healthy controls (NC). Soluble biomarkers of inflammation {high sensitivity C-reactive protein (hs-CRP), Interleukin-6 (IL-6), Soluble Intercellular Adhesion Molecule-1 (sICAM-1), Soluble Vascular Cell Adhesion Molecule-1 (sVCAM-1) and soluble E-selectin} were measured. Results: MS had significant elevation in all biomarkers, while COBXMS had higher concentrations of all biomarkers except sVCAM-1 compared to NC. COBXMS had elevated hs-CRP, IL-6 and sICAM-1 comparable with MS. Obesity categories of subjects (MS, COBXMS or NC) were associated with quartiles of each biomarker concentration (p |
| Databáze: | Directory of Open Access Journals |
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