Association of allergic disease with Parkinson's disease: A nationally representative retrospective cohort study

Autor: Ji Yoon Nam, Sun Jae Park, Jihun Song, Seogsong Jeong, Seulggie Choi, Sang Min Park
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Allergology International, Vol 73, Iss 1, Pp 107-114 (2024)
Druh dokumentu: article
ISSN: 1323-8930
DOI: 10.1016/j.alit.2023.07.005
Popis: Background: The association of allergic diseases such as allergic rhinitis, asthma, and atopic dermatitis with Parkinson's disease (PD) risk is yet unclear. In the few preceding studies, a short follow-up duration was followed for a relatively small study population, and lifestyle behaviors were not adjusted for. Therefore, there is a need for large-scale observation studies on the association of allergic disease with PD risk after considering lifestyle behaviors. Methods: The study population consisted of 398,936 participants aged 40 years or older who underwent health screening before 1 January 2005 from the Korean National Health Insurance Service database. Starting from 1 January 2005, all participants were followed up until the date of PD event, death, or 31 December 2019. The adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for the risk of PD were calculated using multivariable Cox proportional hazards regression. Results: Compared to non-allergic disease participants, allergic disease patients had a higher risk for PD (aHR 1.18, 95% CI 1.07–1.30) and especially, allergic rhinitis patients had a higher risk for PD (aHR 1.14, 95% CI 1.00–1.29). Allergic disease was associated with a higher risk for PD (aHR 1.24, 95% CI 1.01–1.52) among participants who were never smokers, did not consume alcohol, and exercised regularly. Conclusions: Allergic rhinitis was associated with a higher risk for PD compared to participants without allergic rhinitis. This risk-increasing association of allergic rhinitis with PD was preserved even among people with healthy lifestyle behaviors.
Databáze: Directory of Open Access Journals