Efficacy of 5-HT3 receptor antagonists (ondansetron) vs dopamine receptor antagonists (droperidol) for preventing postoperative nausea, vomiting and headache: a meta-analysis
| Autor: | Chen Xiaoyun, Qin Yinying, Li Siying, Lei Heshou, Wu Xiaoyun, Shu LiPei |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Pteridines, Vol 30, Iss 1, Pp 146-152 (2019) |
| Druh dokumentu: | article |
| ISSN: | 0933-4807 2195-4720 2019-0018 |
| DOI: | 10.1515/pteridines-2019-0018 |
| Popis: | Objective To investigate the effects of 5-hydroxytryptamine 3 receptor antagonists (ondansetron [OND]) versus dopamine receptor antagonists (droperidol [DRO]) in the prevention of postoperative nausea, vomiting (PONV) and headache by pooling data from open published studies. Methods Performed systematic electronic searches of PubMed, Embase, Google scholar and CNKI, to identify open-published prospective randomized controlled trials (RCTs) relevant to the comparison of OND versus DRO for preventing PONV and headache to be included in the present study. The pooled PONV, headache, dizziness and drowsiness were calculated based on the original data of each included study. The pooled data was presented with risk ratio (RR) and 95% confidence interval (95%CI). Results Thirteen prospective randomized clinical trials were included in this meta-analysis. The pooled PONV, post-operative nausea (PON) and positive operative vomiting (POV) were 0.67 (95%CI:0.48-0.93, p0.05) and 0.56 (95%CI:0.39-0.82,p0.05), 0.63 (95%CI:0.21-1.87, p>0.05) and 0.48(0.28-0.81,p |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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