| Autor: |
Dong-Hee Kim, Han-Hyuk Kim, Hyeon-Jeong Kim, Hyun-Gug Jung, Jae-Myo Yu, Eun-Su Lee, Yong-Hun Cho, Dong-In Kim, Bong-Jeun An |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Molecules, Vol 19, Iss 5, Pp 6407-6414 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
1420-3049 |
| DOI: |
10.3390/molecules19056407 |
| Popis: |
Ultraviolet (UV) exposure is well-known to induce premature aging, which is mediated by matrix metalloproteinase-1 (MMP-1) activity. A 9-mer peptide, CopA3 (CopA3) was synthesized from a natural peptide, coprisin, which is isolated from the dung beetle Copris tripartitus. As part of our continuing search for novel bioactive natural products, CopA3 was investigated for its in vitro anti-skin photoaging activity. UV-induced inhibition of type-I procollagen and induction of MMP-1 were partially prevented in human skin fibroblasts by CopA3 peptide in a dose-dependent manner. At a concentration of 25 μM, CopA3 nearly completely inhibited MMP-1 expression. These results suggest that CopA3, an insect peptide, is a potential candidate for the prevention and treatment of skin aging. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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