The State of Art of Regenerative Therapy in Cardiovascular Ischemic Disease: Biology, Signaling Pathways, and Epigenetics of Endothelial Progenitor Cells

Autor:	Fabio Perrotta, Angelica Perna, Klara Komici, Ersilia Nigro, Mariano Mollica, Vito D’Agnano, Antonio De Luca, Germano Guerra
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	EPCs cardiovascular ischemic disease regenerative medicine calcium homeostasis regenerative therapy epigenetic Cytology QH573-671
Zdroj:	Cells, Vol 9, Iss 8, p 1886 (2020)
Druh dokumentu:	article
ISSN:	2073-4409
DOI:	10.3390/cells9081886
Popis:	Ischemic heart disease is currently a major cause of mortality and morbidity worldwide. Nevertheless, the actual therapeutic scenario does not target myocardial cell regeneration and consequently, the progression toward the late stage of chronic heart failure is common. Endothelial progenitor cells (EPCs) are bone marrow-derived stem cells that contribute to the homeostasis of the endothelial wall in acute and chronic ischemic disease. Calcium modulation and other molecular pathways (NOTCH, VEGFR, and CXCR4) contribute to EPC proliferation and differentiation. The present review provides a summary of EPC biology with a particular focus on the regulatory pathways of EPCs and describes promising applications for cardiovascular cell therapy.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/0c7aac181d9a428d91ba68006a5e2a2f Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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