Assessment of the effect of sub-lethal acute toxicity of Emamectin benzoate in Labeo rohita using multiple biomarker approach

Autor: Vikas Kumar, Himanshu Sekhar Swain, Basanta Kumar Das, Sankhajit Roy, Aurobinda Upadhyay, Mitesh Hiradas Ramteke, Ramen Kumar Kole, Hemanta Banerjee
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Toxicology Reports, Vol 9, Iss , Pp 102-110 (2022)
Druh dokumentu: article
ISSN: 2214-7500
DOI: 10.1016/j.toxrep.2022.01.001
Popis: Emamectin benzoate (EMB) is a potent neurotoxin agent, widely used for ectoparasites control in aquaculture, but their detailed toxicological implications in Labeo rohita are unknown. Thus, this study was conceptualized to determine the LC50 and to investigate the effects of two sub-lethal concentrations 1/50th of 96 h LC50 (1.82 μgL−1) and 1/10thof 96 h LC50 (9.1 μgL−1) on hemato-immunological and biochemical responses in L. rohita (mean weight 25.54 ± 2.3 g and length 10.35 ± 2.4 cm) for a period of 24 h, 48 h, and 72 h. LC50 of EMB were 163 μgL-1, 112 μgL-1, 99 μgL-1 and 91 μgL-1 at 24 h, 48 h, 72 h, and 96 h respectively. The safe limit at 96 h LC50 of EMB was 2.30 μgL-1. In EMB treated fish, red blood cells, white blood cells, hemoglobin, and hematocrit counts were reduced (p
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