Lesion impacts on long-term outcomes in patients implanted with bioresorbable vascular scaffold

Autor: Yi-Chih Wang, Hsien-Li Kao, Cho-Kai Wu, Mao-Shin Lin, Fu-Tien Chiang, Juey-Jen Hwang
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of the Formosan Medical Association, Vol 121, Iss 8, Pp 1458-1465 (2022)
Druh dokumentu: article
ISSN: 0929-6646
DOI: 10.1016/j.jfma.2021.10.012
Popis: Background: Bioresorbable vascular scaffold (BVS) had been implanted to several kinds of complex coronary lesions in real-world practice. We tested if long-term outcomes of BVS for complex lesions would be worse than that for relatively simple lesions. Methods: We analyzed 457 patients (59 ± 12 years, 87% male) with 714 BVS implanted for their 529 lesions and median follow-up of 32.7 (26.8–39.3) months. Complex group (N = 284) was defined as those with BVS for acute coronary syndrome, chronic total occlusion, bifurcation/ostial lesions, instent restenosis/hybrid with metallic stents, diffuse lesions (overlapped by 2 BVS with each ≧ 18 mm), venous graft/left main lesions, or lesions after rotablation. We compared their outcomes with the remaining 173 patients as non-complex group. Results: The complex group had more chronic kidney disease (7% vs. 2%), multivessel disease (78% vs. 65%), use of intravascular imaging (40% vs. 23%), and more BVS (1.8 ± 0.9 vs. 1.1 ± 0.3) with longer total lengths (47 ± 22 vs. 29 ± 8 mm) implanted than non-complex group (all p 0.05) between the two groups. Multivariate Cox regression analyses showed BVS for ACC/AHA type C lesions was independently associated with higher risks of TLR (hazard ratio: 2.7, 95% CI = 1.1–6.6) and TLF (hazard ratio: 2.6, 95% CI = 1.1–6.3). Conclusion: Comparable outcomes were found between BVS for complex and non-complex lesion category. However, higher risks of TLR and TLF for type C lesions still suggested the prognostic impact of lesion complexity on long-term outcomes of BVS.
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