SWI/SNF subunit BAF155 N-terminus structure informs the impact of cancer-associated mutations and reveals a potential drug binding site
| Autor: | Mark D. Allen, Stefan M. V. Freund, Mark Bycroft, Giovanna Zinzalla |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Communications Biology, Vol 4, Iss 1, Pp 1-7 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2399-3642 50628224 |
| DOI: | 10.1038/s42003-021-02050-z |
| Popis: | Allen et al. determine crystal structure of the N-terminus of SWI/SNF chromatin remodelling factor subunit BAF155. They identify an interconnected structure of MarR-like, BRCT and chromodomains, visualise the potential effect of cancer-associated missense mutations and suggest a binding site and target for small molecule inhibitors. |
| Databáze: | Directory of Open Access Journals |
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