Rapid Construction of Liquid-like Surfaces via Single-Cycle Polymer Brush Grafting for Enhanced Antifouling in Microfluidic Systems

Autor: Feng Wu, Jing Xu, Yuanyuan Liu, Hua Sun, Lishang Zhang, Yixuan Liu, Weiwei Wang, Fali Chong, Dan Zou, Shuli Wang
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Micromachines, Vol 15, Iss 10, p 1241 (2024)
Druh dokumentu: article
ISSN: 2072-666X
DOI: 10.3390/mi15101241
Popis: Liquid-like surfaces have demonstrated immense potential in their ability to resist cell adhesion, a critical requirement for numerous applications across various domains. However, the conventional methodologies for preparing liquid-like surfaces often entail a complex multi-step polymer brush modification process, which is not only time-consuming but also presents significant challenges. In this work, we developed a single-cycle polymer brush modification strategy to build liquid-like surfaces by leveraging high-molecular-weight bis(3-aminopropyl)-terminated polydimethylsiloxane, which significantly simplifies the preparation process. The resultant liquid-like surface is endowed with exceptional slipperiness, effectively inhibiting bacterial colonization and diminishing the adherence of platelets. Moreover, it offers promising implications for reducing the dependency on anticoagulants in microfluidic systems constructed from PDMS, all while sustaining its antithrombotic attributes.
Databáze: Directory of Open Access Journals