Enhancing clinical decision support with genomic tools in breast cancer: A Scottish perspective

Autor: A.L. Peters, P.S. Hall, L.B. Jordan, F.Y. Soh, L. Hannington, S. Makaranka, G. Urquhart, M. Vallet, D. Cartwright, H. Marashi, B. Elsberger
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Breast, Vol 75, Iss , Pp 103728- (2024)
Druh dokumentu: article
ISSN: 1532-3080
DOI: 10.1016/j.breast.2024.103728
Popis: Introduction: The Oncotype DX Breast RS test has been adopted in Scotland and has been the subject of a large population-based study by a Scottish Consensus Group to assess the uptake of the recurrence score (RS), evaluate co-variates associated with the RS and to analyse the effect it may have had on clinical practice.Materials & Methods: Pan-Scotland study between August 2018–August 2021 evaluating 833 patients who had a RS test performed as part of their diagnostic pathway. Data was extracted retrospectively from electronic records and analysis conducted to describe change in chemotherapy administration (by direct comparison with conventional risk assessment tools), and univariate/multivariate analysis to assess relationship between covariates and the RS. Results: Chemotherapy treatment was strongly influenced by the RS (p
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