| Autor: |
Manuel Vázquez Blanco, Hilda Ruda Vega, Roberto A. Guerri-Guttenberg, Rodolfo Giuliano, Daniel R. Grana, Francisco Azzato, José Milei |
| Jazyk: |
angličtina |
| Rok vydání: |
2011 |
| Předmět: |
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| Zdroj: |
Artery Research, Vol 5, Iss 2 (2011) |
| Druh dokumentu: |
article |
| ISSN: |
1876-4401 |
| DOI: |
10.1016/j.artres.2011.02.001 |
| Popis: |
Objective: A systematic histological, morphometric and immunohistochemical (PAI-1 and TGF-β1) study of umbilical vessels in normal and pathological conditions was undertaken in order to describe and compare the lesions found. Methods: Segments of umbilical cords were obtained from 92 pregnancies/107 newborns from normal gestations (n = 20) or from gestational diabetes mellitus (n = 13), chronic hypertension (n = 14), preeclampsia (n = 9), intrahepatic cholestasis (n = 13), antiphospholipid syndrome (n = 11), fetal growth restriction (n = 9), oligohydramnios (n = 6), premature rupture of membranes (n = 12), antiphospholipid antibodies (n = 11) and fetal distress (n = 23). Thirty-four of these patients presented combined pathologies. Results: “Pathological” umbilical cords presented perivascular/intraparietal hemorrhages with wall dissections, parietal recent thrombosis and focal moderate or extensive Wharton’s jelly hemorrhages. Pathological pregnancies presented more microscopic lesions (35/73; 48%) than normal pregnancies (4/20; 20%; p = 0.039). The wall:lumen ratio of arteries was significantly higher in all pathologies (32.6 ± 16) as compared to 3.1 ± 0.6 in the control group (p < 0.0001), also due to the significantly higher values belonging to outer plus inner layer areas in opposition to much less increases in luminal areas (p = 0.03). Concerning veins, wall:lumen ratio was also higher in the pathological groups (p = 0.0086) due to a 2-fold increase in wall areas. Conclusion: Quantitative histomorphometry of the pathological alterations and pathophysiologic disorders of the umbilical cord has the potential to enhance investigation and treatment of maternal and fetal diseases. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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