Microneedles: Characteristics, Materials, Production Methods and Commercial Development
| Autor: | Amina Tucak, Merima Sirbubalo, Lamija Hindija, Ognjenka Rahić, Jasmina Hadžiabdić, Kenan Muhamedagić, Ahmet Čekić, Edina Vranić |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Micromachines, Vol 11, Iss 11, p 961 (2020) |
| Druh dokumentu: | article |
| ISSN: | 11110961 2072-666X |
| DOI: | 10.3390/mi11110961 |
| Popis: | Although transdermal drug delivery systems (DDS) offer numerous benefits for patients, including the avoidance of both gastric irritation and first-pass metabolism effect, as well as improved patient compliance, only a limited number of active pharmaceutical ingredients (APIs) can be delivered accordingly. Microneedles (MNs) represent one of the most promising concepts for effective transdermal drug delivery that penetrate the protective skin barrier in a minimally invasive and painless manner. The first MNs were produced in the 90s, and since then, this field has been continually evolving. Therefore, different manufacturing methods, not only for MNs but also MN molds, are introduced, which allows for the cost-effective production of MNs for drug and vaccine delivery and even diagnostic/monitoring purposes. The focus of this review is to give a brief overview of MN characteristics, material composition, as well as the production and commercial development of MN-based systems. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|