| Autor: |
Bartholomew Chukwuebuka Nwogueze, Anthony Emeka Ojieh, Josiah Iju Wilson, Simon Irikefe Ovuakporaye, Peggy Ejiro Ohwin, Eromosele Michael Aisuodionoe, Tarela Melish Elias Daubry, Ejime Agbonifo-chijiokwu, Chidinma Nwanneamaka Eke, Oghenerukevwe Omeru, Emmanuel Ikemefune Ebuwa, Chukwuemeka Peter Aloamaka |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Biomedicine & Pharmacotherapy, Vol 143, Iss , Pp 112208- (2021) |
| Druh dokumentu: |
article |
| ISSN: |
0753-3322 |
| DOI: |
10.1016/j.biopha.2021.112208 |
| Popis: |
This study was designed to physiologically investigate the fate of stress related infertility conditions to focus on the regulatory response of reproductive potentials in stress-induced female Wistar rats supplemented with clomifene citrate. 42 apparently healthy female Wistar rats weighing about 120–160 g were used in the study. The animals were randomly distributed into 3 groups after acclimatization for 2 weeks. Group 1 served as the control pregnant rats not induced by restraint, mirrored and intruder stressors, group 2 consisted of rats treated with 0.013 mg/g of clomifene citrate drug and exposed to three different stressors while group 3 represented pregnant rats exposed to different stressors but not treated with clomifene citrate. At the end of 3weeks, the rats were euthanized via cervical dislocation. The uterus and ovary organs were carefully isolated, weighed and examined for histological changes. The reproductive capacities studied were gestation period, mean pup weight, litter size and survival rate respectively. Data collected is expressed in Mean±SEM and one way ANOVA statistics was used for comparison of means while Fisher’s LSD was employed for post hoc test and the level of significance is determined at p-value |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect