| Autor: |
Sara Nascimento, Marta Rodrigues, Manuel Gonçalves Henriques, Fernanda Paixão Duarte, António Barra, Teresa Matos |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Case Reports in Women's Health, Vol 27, Iss , Pp e00238- (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2214-9112 |
| DOI: |
10.1016/j.crwh.2020.e00238 |
| Popis: |
The anti-PP1Pk is a rare antibody associated with recurrent miscarriages, mainly in the first half of pregnancy. There seems to be a direct correlation between the antibody titer and risk of miscarriage. As this is a rare entity, few case reports have been published. The most frequently proposed therapeutic approaches are double-filtration plasmapheresis and plasma exchange therapy. The rationale behind them is to remove the cytotoxic antibodies from maternal circulation. Here, we present the case of a 30-year-old woman with a history of two spontaneous miscarriages and a pre-conception anti-PP1Pk antibody titer of 1:4. As soon as she became pregnant, she was placed on prednisolone and low-molecular-weight heparin (LMWH). Biweekly antibody titers were performed throughout the entire gestation and remained below 1:16. As the titers were considered to be low, plasmapheresis was not performed. The pregnancy was uneventful and she delivered a healthy newborn child at 37 weeks of gestation, with no signs of anaemia. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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