Cardiac troponin concentrations following exercise and the association with cardiovascular disease and outcomes: rationale and design of the prospective TREAT cohort study

Autor: Maria T E Hopman, Thijs M H Eijsvogels, Otto Bekers, Robin Nijveldt, Jesse Habets, Monique Brink, Kristian Berge, Vincent L Aengevaeren, Sylvan L J E Janssen, Sacha K Lamers, Wim H M Vroemen, Ellen J S Denessen, Wouter M Van Everdingen, Alma M A Mingels
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: BMJ Open Sport & Exercise Medicine, Vol 10, Iss 2 (2024)
Druh dokumentu: article
ISSN: 2055-7647
DOI: 10.1136/bmjsem-2024-002070
Popis: Exercise can produce transient elevations of cardiac troponin (cTn) concentrations, which may resemble the cTn release profile of myocardial infarction. Consequently, clinical interpretation of postexercise cTn elevations (ie, values above the 99th percentile upper reference limit) remains challenging and may cause clinical confusion. Therefore, insight into the physiological versus pathological nature of postexercise cTn concentrations is warranted. We aim to (1) establish resting and postexercise reference values for recreational athletes engaged in walking, cycling or running exercise; (2) compare the prevalence of (sub)clinical coronary artery disease in athletes with high versus low postexercise cTn concentrations and (3) determine the association between postexercise cTn concentrations and the incidence of major adverse cardiovascular events (MACE) and mortality during long-term follow-up. For this purpose, the prospective TRoponin concentrations following Exercise and the Association with cardiovascular ouTcomes (TREAT) observational cohort study was designed to recruit 1500 recreational athletes aged ≥40 to
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