| Autor: |
Fei Wen, Shangyu Yang, WeiWen Cai, Mengyuan Zhao, Long Qin, Zuoyi Jiao |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Molecular and Cellular Probes, Vol 72, Iss , Pp 101931- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
0890-8508 |
| DOI: |
10.1016/j.mcp.2023.101931 |
| Popis: |
Although there are several treatments available for gastric cancer (GC), the prognosis of the disease is still poor due to many factors, such as late diagnosis and tumor heterogeneity. To identify potential therapeutic targets, bioinformatics techniques and clinical sample validation were employed and prostate transmembrane protein androgen induced 1 (PMEPA1) was selected for further study. In the present study, we found that elevated PMEPA1 expression correlates with a worse prognosis and weaker anti-tumor immunity in GC patients. Moreover, our study showed that PMEPA1 not only influences cell proliferation, clone formation, invasion, and migration in vitro, but also plays an important role in GC progression in vivo. Mechanically, PMEPA1 exerts its oncogenic effects through activating the Wnt/β-catenin signaling pathway. Therefore, PMEPA1 is a potential target for treating GC effectively. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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