Ubiquitin and ubiquitin-like molecules in DNA double strand break repair

Autor: Jia Yu, Bo Qin, Zhenkun Lou
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Cell & Bioscience, Vol 10, Iss 1, Pp 1-10 (2020)
Druh dokumentu: article
ISSN: 2045-3701
DOI: 10.1186/s13578-020-0380-1
Popis: Abstract Both environmental and endogenous factors induce various forms of DNA damage. DNA double strand break (DSB) is the most deleterious DNA lesion. The swift initiation of a complexed network of interconnected pathways to repair the DNA lesion is essential for cell survival. In the past years, the roles of ubiquitin and ubiquitin-like proteins in DNA damage response and DNA repair has been explored. These findings help us better understand the complicated mechanism of DSB signaling pathways.
Databáze: Directory of Open Access Journals
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