Anti--methyl-D-aspartate receptor encephalitis associated with ovarian teratoma in Korea: three case reports

Autor: Jisun Lee, Seongwoo Kang, Hye Jin Chang, Yong Hee Lee, Joo-Hyuk Son, Tae Wook Kong, Suk-Joon Chang, Kyung Joo Hwang, Miran Kim
Jazyk: English<br />Korean
Rok vydání: 2021
Předmět:
Zdroj: Yeungnam University Journal of Medicine, Vol 38, Iss 4, Pp 350-355 (2021)
Druh dokumentu: article
ISSN: 2384-0293
DOI: 10.12701/yujm.2020.00794
Popis: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe autoimmune paraneoplastic syndrome associated with ovarian teratomas. Most patients develop neurologic symptoms, including psychosis, memory deficits, seizures, or abnormal movements, and experience abdominal pain related to ovarian neoplasm. We present a case report of three patients diagnosed with anti-NMDAR encephalitis accompanied by ovarian teratomas at Ajou University Hospital in Korea. The patients demonstrated a different clinical course of the disease. However, upon diagnosis, all patients underwent surgical removal of the ovarian teratoma followed by intensive immunotherapy. The symptoms progressively improved following treatment. This is a case report of a rare autoimmune anti-NMDAR encephalitis associated with ovarian neoplasms, including immature teratoma.
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