Deep gray matters iron deposition is positively associated with white matter hyperintensity in hypertension

Autor: Yu Su, Wenjun Wu, Ziji Qin, Chungao Li, Jie Zhao, Jiamin Kang, Youzhi Wang, Chuansheng Zheng, Ewart Mark Haacke, Lixia Wang
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: The Journal of Clinical Hypertension, Vol 25, Iss 8, Pp 768-777 (2023)
Druh dokumentu: article
ISSN: 1751-7176
1524-6175
DOI: 10.1111/jch.14694
Popis: Abstract The association and underlying mechanisms between iron deposition and white matter hyperintensity (WMH) remain unclear. In this study, quantitative susceptibility mapping (QSM) was used to quantify deep gray matters iron deposition and to explore the association from both global and regional perspectives. A total of 84 patients with hypertension and 26 healthy controls underwent a strategically acquired gradient echo (STAGE) protocol, and the multi‐echo data were used to reconstruct QSM images. The susceptibilities were used to describe iron content. Global region (RI) susceptibilities were measured in regions of interest, and age‐related thresholds were used to determine high‐iron content region (RII) susceptibilities. Compared with healthy controls, hypertension had higher total WMH scores and regional scores (all p = .001) and higher susceptibilities using the RI or RII analysis (all p
Databáze: Directory of Open Access Journals
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