| Autor: |
Conner C. Earl, Victoria I. Pyle, Sydney Q. Clark, Karthik Annamalai, Paula A. Torres, Alejandro Quintero, Frederick W. Damen, Kan N. Hor, Larry W. Markham, Jonathan H. Soslow, Craig J. Goergen |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Journal of Cardiovascular Magnetic Resonance, Vol 25, Iss 1, Pp 1-17 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1532-429X |
| DOI: |
10.1186/s12968-023-00922-3 |
| Popis: |
Abstract Background Cardiomyopathy (CMP) is the most common cause of mortality in Duchenne muscular dystrophy (DMD), though the age of onset and clinical progression vary. We applied a novel 4D (3D + time) strain analysis method using cine cardiovascular magnetic resonance (CMR) imaging data to determine if localized strain metrics derived from 4D image analysis would be sensitive and specific for characterizing DMD CMP. Methods We analyzed short-axis cine CMR image stacks from 43 DMD patients (median age: 12.23 yrs [10.6–16.5]; [interquartile range]) and 25 male healthy controls (median age: 16.2 yrs [13.3–20.7]). A subset of 25 male DMD patients age-matched to the controls (median age: 15.7 yrs [14.0-17.8]) was used for comparative metrics. CMR images were compiled into 4D sequences for feature-tracking strain analysis using custom-built software. Unpaired t-test and receiver operator characteristic area under the curve (AUC) analysis were used to determine statistical significance. Spearman’s rho was used to determine correlation. Results DMD patients had a range of CMP severity: 15 (35% of total) had left ventricular ejection fraction (LVEF) > 55% with no findings of myocardial late gadolinium enhancement (LGE), 15 (35%) had findings of LGE with LVEF > 55% and 13 (30%) had LGE with LVEF 55%) compared to a healthy control group (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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