Anti-Toxoplasma gondii antibodies as a risk factor for the prevalence and severity of systemic lupus erythematosus

Autor: Zhongzhen Li, Zhiwei Lei, Wanying Yang, Chunxia Jing, Xiaolin Sun, Guang Yang, Xiaozhen Zhao, Mingjiao Zhang, Miaomiao Xu, Yuanjia Tang, Qingwen Wang, Jing Zhao, Zixing Zhou, Zihao Wen, Xiaojing Chen, Qinglin Peng, Guochun Wang, Pingjing Zhang, Erwei Sun, Nan Shen, Weiguo Xu, Zhanguo Li, Hengwen Yang, Zhinan Yin
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Parasites & Vectors, Vol 17, Iss 1, Pp 1-8 (2024)
Druh dokumentu: article
ISSN: 1756-3305
DOI: 10.1186/s13071-024-06141-8
Popis: Abstract Background Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease characterized by the presence of numerous autoantibodies. The interaction of infectious agents (viruses, bacteria and parasites) and a genetically susceptible host may be a key mechanism for SLE. Toxoplasma gondii is a widespread intracellular parasite that has been implicated in the pathogenesis of autoimmune diseases. However, the relationship between T. gondii infection and the increased risk of SLE in Chinese populations remains unclear. Methods The seroprevalence of T. gondii infection was assessed in 1771 serum samples collected from Chinese individuals (908 healthy controls and 863 SLE patients) from different regions of China using an enzyme-linked immunosorbent assay. Serum autoantibodies and clinical information were obtained and analysed. Results Our observations revealed a higher prevalence of anti-T. gondii antibodies (ATxA) immunoglobulin G (IgG) in serum samples from SLE patients (144/863, 16.7%) than in those from the healthy controls (53/917, 5.8%; P
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