Eculizumab for paroxysmal nocturnal haemoglobinuria: catastrophic health expenditure in Nepalese patients

Autor:	Sugat Adhikari, Surendra Sapkota, Suraj Shrestha, Kshitiz Karki, Anjan Shrestha
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Catastrophic health expenditure Eculizumab Low and middle-income countries Orphan drug Paroxysmal nocturnal hemoglobinuria Nepal Medicine
Zdroj:	Orphanet Journal of Rare Diseases, Vol 18, Iss 1, Pp 1-4 (2023)
Druh dokumentu:	article
ISSN:	1750-1172
DOI:	10.1186/s13023-023-02779-2
Popis:	Abstract Paroxysmal nocturnal hemoglobinuria (PNH) results from a mutation in the phosphatidylinositol glycan class-A gene which causes uncontrolled complement activation with resultant intravascular hemolysis and its sequelae. Eculizumab is a terminal complement inhibitor that blocks this complement activation and has revolutionized the treatment of PNH but comes with an enormous price which can have catastrophic health expenditure in low-middle income countries (LMIC) like Nepal. Here, we discuss the potential way forwards in the treatment of PNH in Nepal and other LMICs.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/d0bb79ecc1fe4de48f75c5c2a4df956d Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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