Cholinesterase, tyrosinase inhibitory and antioxidant potential of randomly selected Umbelliferous plant species and chromatographic profile of Heracleum platytaenium Boiss. and Angelica sylvestris L. var. sylvestris
| Autor: | Orhan Ilkay Edrogan, Tosun Fatma, Skalicka-Woźniak Krystyna |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Journal of the Serbian Chemical Society, Vol 81, Iss 4, Pp 357-368 (2016) |
| Druh dokumentu: | article |
| ISSN: | 0352-5139 1820-7421 |
| DOI: | 10.2298/JSC150902017O |
| Popis: | Neurobiological activity of the methanol extracts of thirteen Umbelliferae (Apiaceae) plants was tested against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and tyrosinase (TYR) using high-throughput screening technique. Although the extracts displayed none to low profile of inhibition against enzymes, the highest cholinesterase inhibition was observed with Heracleum platytaenium (32.52 ± 3.27 % for AChE and 46.16 ± 1.42 % for BChE) at 100 μg mL-1. Since neurodegeneration is linked to oxidative damage, antioxidant potential of the extracts was searched through radical scavenging, metal-chelating capacity, and reducing power experiments and exerted modest levels of activity varying according to the method. The extracts had a better ability to scavenge nitric oxide radical (19.47 ± 2.09 % to 54.91 ± 1.98 %). Since these species are known to be rich in coumarins, our quantitative high-performance liquid chroatography (HPLC) analysis indicated presence of xanthotoxin, angelicin, isopimpinellin, bergapten, and pimpinellin in Heracleum platytaenium and angelicin and imperatorin in Angelica sylvestris var. sylvestris. |
| Databáze: | Directory of Open Access Journals |
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